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Understanding Two Heart Problems by Studying the Domino Effect of One Gene Network

The main function of cardiomyocytes, the heart muscle cells is pumping blood to other organs of the body. However, they can also carry genetic instructions and function as a nerve cell, liver cell, intestinal cell or any other cell type in the body.

Dr. Deepak Srivastava says, “At the moment in time that the fetal heart begins to develop, master switch proteins, called transcription factors, act like the first tile in an extremely complex pattern of dominos and set off a chain of events which lead to the activation of heart muscle specific genes in cardiomyocytes as well as the silencing of genes important for the development other cells types.”

The process creates functioning hearts in over 355000 babies born every day. However, it is not entirely flawless and often leads to heart defects. It’s noticed that almost 1% of babies are born with heart defects.

Gladstone Institutes scientists have studied a family with a history of heart defects in order to understand how gene network acts in a wrong way that may cause heart defects and even heart diseases in the later stages of life. In 2003, the family consulted Deepak Srivastava, the head of the cardiovascular institute at Gladstone. Their problem was critical and rare. Half of the kids in the family were born with a hole in the wall between the two chambers of their hearts.

After an analysis, the Gladstone team found that all the children, born with a hole in the wall, had a mutation in their GATA4 gene. It leads to a heart transcription factor protein. All the children developed a heart disease such as poor heart pumping after seven years. Even though the two heart diseases were not directly related, however, Srivastava’s team believed that GATA4 mutation was responsible for both.

The team was eager to fissure out how the GATA4 mutation could lead to the two heart problems. In the process, they collected skin samples of the children and created cardiomyocytes. They also collected samples from their healthy siblings, so that they could conduct a comparative analysis in the laboratory. All the tests showed that the cells with GATA4 mutation demonstrate weakened function in comparison with the healthy cells.

The team also examined how the GATA4 protein interacted with protein TBX5. It’s seen that both the proteins control genes by interacting and binding to DNA. The study showed that in the cells with damaged GATA4, protein TBX5 did not tie well with the DNA. The team also found that GATA4 mutation creates an obstacle in the interaction with TBX5, so the non-heart specific genes cause more disturbances in cardiomyocyte development.

Deepak Srivastava stated, “By studying the patients’ heart cells in a dish, we were able to figure out why their hearts were not pumping properly. Investigating their genetic mutation revealed a whole network of genes that went awry, first causing septal [heart wall] defects and then the heart muscle dysfunction.”

GATA4 and TBX5 are the first domino tiles that belong to an intricate network of genes. So thinking of a treatment with these proteins would not be practical. Moreover, if they are blocked, they might lead to a worse situation. So, finding a medicine that would impact a particular set of GATA4/TBX5 actions might lead to a new therapy to cure heart diseases.

Yen-Sin Ang, the first author on the report, said, “It’s amazing that by studying genes in a two-dimensional cluster of heart cells, we were able to discover insights into a disease that affects a complicated three-dimensional organ. We think this conceptual framework could be used to study other diseases caused by mutations in proteins that serve as master regulators of whole gene networks.”

Blood Pressure: Caused By Salt Or Is It Just A Myth?

Every second person you speak to seems complaining or suffering from some sort of cardiovascular issues. Measuring blood pressure indicates the force against the wall of the arteries, as well the pumping of the heart.

Most people are of the opinion that salt is the biggest culprit for cardiovascular disease, or at least they’ve been told so? The theory that salt is bad for you and increases heart disease is an old hat and been proven wrong for decades. To reduce salt too much has had a number of draw backs and is affecting other things in your body.

There is strong evidence, that not salt is the main issue for high blood pressure but incorrect potassium to sodium balance is. Not having the right balance between the two of them increases the risk for hypertension and heart disease by far more than salt or high levels of sodium alone.

Which Salt?

Most people are not aware of the fact that potassium is an essential mineral which plays an important role in regards to your blood pressure. What matters is the balance between salt and potassium. The first step: Replace the refined table salt with natural salt for a better balance of potassium. As salt is getting the blame for high blood pressure, sugar and trans fats are far worse and having the most impact for cholesterol and heart disease.

Lacking Potassium

In general, our diet being the biggest amount of processed foods consumed by many, which is lacking of potassium. To lower salt levels in processed foods, monosodium glutamate (MSG) being added to processed food, two things happened: This enhanced the flavor in foods and reduced the salt, but created a number of other health problems. What this meant, processed food with all its preservatives, flavor enhancer (MSG) etc. which in general gives the average person twice as much sodium as potassium. As well the other thing is mineral and magnesium deficiency, of which is very little found in processed food; this is also damaging your heart and arteries. Magnesium is critical for healthy blood pressure and is too often lacking in our daily diet. Magnesium also helps lower blood volume, supports blood vessels and keeps the arteries smooth and elastic.

What We Eat

As we know too many processed foods are the trigger point for most illnesses. These foods are high in refined sugar, refined sodium, trans – fats which is the main cause for high blood pressure. Changing to a more natural diet will improve overall condition including lowering of blood pressure and cholesterol. We should eat more of the leafy greens, vegetables, mushrooms, berries, avocados, natural Creek yogurt, wild caught salmon, fish oil etc. Another one is grape seed extract which is an excellent blood pressure support. As grapes are high in fructose which can worsen insulin and leptin resistance. Using grape seed extract will not affect the insulin level, it will help blood pressure, cholesterol and blood sugar level.

Such foods that have a high amount of potassium, magnesium and minerals to lower blood pressure, as well to improve your overall health, are a safe, natural comprehensive protection without any side effects. Medical research has discovered literally thousands of healing nutrients in foods.

Food is the cause of most of our health problems, and food is also the solution. The most important step to a healthy life is the change to a healthy diet! Also, a safe measure and protection to add a good multi supplement that has a variety of minerals and all the nutrients.

Medication Needs

Reducing medication to avoid some of the risky side effects even from warfarin, people have looked to aspirin for daily heart support. Taking aspirin every day for blood thinning and to reduce stroke risk is not a cure or a satisfactory alternative.

Although, aspirin is not as harmful as many other medications, aspirin is a natural pain reliever and one of the safest ones to use, as well it lowers fever and inflammation. Some of the later research has found that aspirin is not the answer for blood pressure and thinning of blood as previous thought.

Some medication may be excepted for short-term use. The longer to stay on medication the higher becomes the risk factor and the increase of side effects.

My name is Josef Bichler. I have a passion for wellness and showing others how to live healthy lives. I have corrected my own health problems with the use of alternatives only. I have helped many others achieve their health objectives by exposing unhealthy foods, the dangers of some medication and it’s after effects. To make people aware, and show them how to avoid most of the culprits that affects our health. For more ongoing health information subscribe to my free weekly newsletters, this also gives you the opportunity for comments, suggestions and questions you may have.

What Is Carotid Artery Disease?

What is a Carotid Ultrasound?

Carotid ultrasound is sometimes called Doppler testing. It’s able to determine if your artery walls are narrowed and if you have some plaque in your arteries. It also shows a number of other important factors that include the direction and speed of your blood flow. It also includes the pressure of the blood on the artery walls, as well as the location of any potential blood clots.

If you have recently undergone surgery on your carotid arteries, this ultrasound will show how effective the procedure has been. It’s also used to determine the placement of a stent. It is a specialized type of mesh tube that is carefully inserted into the artery to help improve the blood flow by keeping the artery open and clear. A carotid ultrasound can also determine the effectiveness of the stent during follow-up visits with your cardiologist.

Will This Test be Uncomfortable or Painful?

The really nice thing about this test is that it is completely painless and non-invasive as it simply involves having an ultrasound wand moved over your neck. This will provide your cardiologist with real-time images of the blood flow in the arteries that are shown on a screen.

Sometimes this type of test will be used in conjunction with other procedures to provide a more definitive diagnosis. These tests may include CT scan, x-rays or an MRI. Maybe even an angiography which is a different type of scan where an injected dye will highlight any abnormalities in the arteries.

Who Should Have a Carotid Ultrasound?

A carotid ultrasound may be required to diagnose a problem or as part of a follow-up appointment for previous treatment. Your cardiologist may suggest this test as part of a routine preventative examination. For example; if you are more at risk of developing coronary heart disease. This could be the case if you have certain risk factors or a family history of this disease.

It might be worth having a carotid ultrasound if you have high blood pressure or high cholesterol, already have coronary artery disease or a family history of this disease. Even if your physician has picked up abnormal sounds on a stethoscope.

People who are particularly inactive or who smoke or who are extremely overweight may also benefit from this test. The great thing about this type of test is that when used as a preventative measure, it can detect the early signs of plaque buildup in the arteries. Hopefully, before any damage caused to the arteries is permanent.

Plaque consists of fat and calcium, and excess cholesterol. It tends to develop as a result of a lack of exercise or due to poor diet. The plaques that develop in arteries are initially soft and are filled with cholesterol, but if they rupture then they can cause an injury at the rupture site.

This resulting scar tissue will eventually become calcified. These areas of calcified healed plaque can interrupt the flow of blood, increasing the risk of blood clots that are more likely to block the blood vessels.

By detecting the presence of plaque at an early stage, your cardiologist will be able to provide medications to help reduce your risk of heart disease. Additionally, you will be able to make modifications to your lifestyle to help reverse the process.

This test can be a highly beneficial preventative procedure. Especially as it’s estimated that carotid artery disease causes between 10% and 20% of all strokes in the United States. There is the potential that this test could save your life, as a stroke could leave you with permanent brain damage or may even be fatal.

If you are interested in preventing any form of heart disease or have a family history of heart problems, it could be well worth scheduling an appointment your doctor.

Aged Garlic Clove Extract and Blood Pressure

Searching for natural high bloodstream pressure remedies has become more pronounced mainly due to the dreaded negative effects of a few of the hypertension medications. Another reason has additionally been the price of purchasing hypertension medications much more within the developing countries asia and Africa.

Aside from these 4 elements, doctors generally encourage changes in lifestyle in working with hypertension issues. People are likely to drastically reduce their daily sodium intake from the a lot of 5400mg to some low of 1500mg if at all possible or at best 2300mg. People are also asked to stay healthy via activities and cardio. Eating plenty of fruits and vegetables can also be essential in getting high bloodstream pressure in check.

Herbs that lower BP have consequently gain popularity poor an increasing need for patients to locate these alternative natural treatments for hypertension. Among various herbs under pursuit is Garlic clove. Garlic clove continues to be discusses and regarded for some time to be advantageous to hypertensive conditions. Research conducted recently brought by Dr Karin Ried in the College of Adelaide went one step further by particularly isolating aged garlic extract like a considerable means to fix hypertension.

They spent three several weeks inside a trial involving 50 people. The research during this time period established that individuals with a systolic BP studying above 140 who administered garlic clove extract capsules enjoyed a typical stop by systolic BP of 10.2 mmHg less than the control group which required fake capsules. The study noted that aged garlic extract was more efficient than raw or cooked aged garlic or perhaps powder garlic clove.

These results connected with garlic clove extract are particularly significant just because a fall in systolic BP by 5 mmHg eliminates the chance of coronary disease which could trigger stroke, heart failure and cardiac arrest by a few 8 to twenty percent. The actual scientific mechanisms behind the potency of garlic clove lays behind caffeine substance nitric oxide supplement (NO) and hydrogen sulphide (H2S) which are recognized to aid the relaxing of bloodstream vessels. When bloodstream vessels are stiff and hardened, BP is within turn elevated.

The capacity of herbs, vegetables and general changes in way of life can’t be underestimated inside the mission to control circulatory system weight. Garlic clove extricate containers are situated in many driving disconnected a web based drug stores including Amazon. com. As more patients search for means and the approaches to lessen BP without progressing on medications herbs for instance garlic clove concentrate is just going to have more well known.

How Blood Pressure and Heart Attack Are Related

A heart attack is one of the most common reasons that cause almost 65% deaths annually as many reports suggest. It can occur anytime without giving any signs, but it doesn’t imply that one cannot know the chances of being in the danger zone of getting a stroke. There are plenty of reasons that can result in heart attacks, but blood pressure (BP) is closely related to it, and in most of the cases, it is the BP that triggers the heart attack.

Generally, people with high BP comes in the zone that is more prone to suffer a heart attack, but many recent studies state that low BP too can be a reason while most of them still stick that low blood pressure can never lead to a heart attack. No matter whether you have high or low BP, seeking medical guidance and ways to deal with it in order to prevent heart attack should be your primary concern.

With the main motive of keeping your BP under control to defeat and prevent yourself from being a sufferer of heart attack, we are discussing the causes, symptoms and other essentials.

Causes of high blood pressure

• Smoking
• Hypertension
• Family history
• Stress
• Genetics
• Too much consumption of salt
• Overweight
• Obesity

Causes of low blood pressure

• Pregnancy
• Heart diseases
• Dehydration
• Endocrine problems
• Severe allergy
• Blood loss
• Severe infection

Symptoms of high blood pressure

It is termed as “Silent Killer, ” and it has very few symptoms.
• Headaches
• Dizziness
• Nose Bleeding
• Blood spots in eyes

Symptoms of low blood pressure

• Dizziness
• Fainting
• Lack of concentration
• Nausea
• Blurred vision
• Pale skin
• Fatigue
• Slow breathing

Controlling High Blood Pressure

If you suffer from high BP, you can, of course, control it if you wish to. Below, we have shared a few steps you can take to control your high BP,
• Losing weight and getting in shape
• Quit smoking at the earliest
• Eat a healthy diet precisely DASH diet which means include more fruits and vegetables and consume fat dairy product in a small amount
• Lower the consumption of salt in your food
• Do regular aerobic exercise
• Limit your alcohol consumption

Controlling Low Blood Pressure

Controlling low pressure is equally important. Below, we have shared a few steps through which you can control your low BP.
• Consume salt in higher amount
• Start drinking lots of different types of drinks and limit your alcohol consumption
• Consult a doctor to see if any medication is causing you to suffer from low blood pressure
• Do regular exercise to maintain your blood flow
• Do lift heavy weight material
• Don’t indulge in hot water for a longer time, be it shower or spa
• If you are feeling dizziness frequently, limit the diet and eat smaller diet

So, these are all you want and need to know pressure and if you are suffering from any of these, start implementing the ways to control it right away. It is better to stay from anything that is closely related to the heart attack.

Getting Relief From Heart Disease With Ayurveda

Till eighties, there was a belief that once you suffer from a heart disease, there is virtually nothing which can be done to stop or reverse the harm done. But according to the recent studies, it has been proven that Ayurveda can not only put a stop to the harm being done to arteries, but can also reverse the blockage. Certain Ayurveda practices contribute in increasing the blood flow to specific regions of the heart where adequate blood is not reaching. The coronary arteries get blocked because of inadequate blood supply.

What Do You Mean By Heart Disease?

Heart disease or coronary diseases are the commonest form of heart disease. The disease is actually malfunctioning of blood vessels which can also be a reason for fatal heart attack. One of the many cardiovascular diseases, heart diseases is the disease of the blood vessel system and heart. Some more common cardiovascular diseases include angina or chest pain, Rheumatic heart disease, stroke and high blood pressure.

Some of the reasons for contracting heart diseases are smoking, high blood cholesterol level, high blood pressure, diabetes, physical inactivity and obesity.

Home Remedies for Managing Heart Disease and Avoid It

  • Half teaspoons of ginger and garlic juice taken equally and when mixed with jaggery or honey, it makes the right tonic to be taken twice a day.
  • Juice of pumpkin, carrot and pomegranate, take around 2 glasses daily.
  • ½ tsp Methi seeds if soaked throughout one night in ½ cup water. Chew it the next day morning before taking anything else.
  • Practice Panchkarma to maintain heart dhara as it supports the right way of heart functioning. It also helps in maintaining Shirodhara that balances emotions. Do it under the supervision of an Ayurvedic practitioner.
  • Take a roll of cotton and soak it in warm sesame oil or ghee. Apply the pack of cloth for around fifteen minutes daily around the left side of your chest. This strengthens the heart functioning.
  • ½ tsp cow ghee is to be applied on your both temples and to be massaged gently for a minute. It will reduce stress and anxiety and will help you get peaceful sleep.
  • Meditation, brisk walking, yoga such as Kapalbharti and Anulom Vilom Pranayam should be a routine for daily basis.

People who suffer from diabetes also have annoying food cravings. Eat few healthy recipes to control food cravings.Healthy food recipes to be followed

1. Vegetable chila made of multi grain mix flour, Moong dal flour, salt, ginger garlic paste, coriander leaves chopped, grated bottle gourd, cabbage, green chili finely chopped, Turmeric powder and water.

2. Dalia salad made of crushed dalia, crushed onion and coriander leaves that are finely chopped.

There are various other Ayurvedic home remedies available which you can follow to control diabetes and heart disease. Take a diet meant for Detox to control the levels of blood sugar and improved heart functioning.

Fasting withy only ginger juice in lukewarm water for days can also help you stay healthy and fit.

Take only vegetables and Moong dal soup for 5 days at a stretch and after that for next five days consume only Moong dal and vegetable mixed with garlic and ginger paste, garam masala and turmeric powder.

After all these, start following a normal diet and following the above diet for Detox once a month will help you reduce extra fats, stiffness, swelling and Aam from your body. It will make you feel more agile, healthy and also aid in controlling your weight.

Many medicines are available in the market to keep your heart functioning properly, but unfortunately all of them are not as effective as expected. So, instead of consuming random medicines for heart ailments you can opt for the natural way with Ayurveda which has no adverse effects on the body and will help you get treated naturally. The various natural and Ayurvedic ingredients that are used in medicines for heart ailments are as follows:

Amla: Amla is a potent anti-oxidant that restricts strongly the free radicals from damaging the arteries. It also nourishes the heart tissues and helps in boosting your immune system along with your heart. This amazing fruit is one of the prime ingredients in Chywanaprash which is a delicious jam made with different types of natural herbs and gives strength and immunity.

Arjuna: Heart diseases are caused mainly because of congestion, hardening and inflammation of the arteries that causes restriction in blood flow. These hardened arties also put a lot of pressure on heart tissues and muscles. Known as Ayurveda’s wonder, this herb helps in the reducing congestive arteries, cardiac muscles strengthening and keeping the blood pressure low.

Triphala: Triphala is a perfect cure for people suffering from high cholesterol. It when combined with other herbs also breaks down the blood fats present in the body fast and effectively.

Ashwagandha: Tension is another cause of heart diseases and that is when this wonderful herb Ashwagandha comes to your rescue. It is known for reducing tension of the mind and the body and also helps in heart muscle strengthening.

Fortunately there is a lot more useful information about all aspects of health through Ayurveda, available on our website. The website also has some very effective Ayurvedic Solutions for many chronic problems under section ‘Exclusive Remedies’.

Understanding The Risk Factors of Cardiovascular Disease

When it comes to cardiovascular disease or CVD, there are two types of risk factors – those you can control and those you cannot. Knowing the different risk factors, both controllable and uncontrollable can help you take proper steps to stay healthy and keep problems at bay.

Factors You Can Control


Hypertension or high blood pressure is the leading cause of premature death due to cardiovascular disease. The high pressure overworks and weakens the heart muscles, resulting in cardiovascular problems. Those who have hypertension are also more likely to develop other complications.


Diabetes or high blood sugar increases the risk of cardiovascular problems about 2 to 3 times. The higher the sugar levels, the higher the risk. Unfortunately, diabetes is often diagnosed too late, resulting in serious complications such as strokes, blindness, amputations and CVD.

Sedentary Lifestyle

Leading a sedentary lifestyle is the 4th leading risk factor for cardiovascular disease. Insufficient physical activity can put you at higher risk for hypertension, diabetes and obesity, all of which are precursors for CVD. Engaging in at least 30 minutes of moderate intensity activity 3-4 times a week can lower your risk significantly.


People who are overweight usually also have high blood sugar, high blood pressure and glucose intolerance. All of these conditions put considerable pressure on the arteries and heart muscles, resulting in cardiovascular disease.

High Cholesterol

Statistics indicate that high cholesterol is responsible for about 1/3rd ischaemic heart disease globally. When your cholesterol level is high, fatty deposits form within the blood vessels. These fatty deposits narrow the diameter of the blood vessels, obstructing the free flow of blood to the heart. This insufficient blood flow weakens and damages the cardiovascular muscles increasing the risk of stroke.

Using Tobacco

Smoking or ingesting tobacco hardens the arteries and obstructs blood flow to the heart. As much as 10 % of all related problems are related to tobacco use, especially smoking. Some studies have shown that the risk reduces significantly within 2 years of abstaining from tobacco use.

Unhealthy Diet

What you eat plays a huge role in leading to cardiovascular disease or protecting you from it. Consuming too much salt, processed foods or saturated fats and not enough vegetables, fruit and fish are detrimental to the health of your heart. A healthy diet consisting mainly of vegetables, fruit and fish reduces the risk of diabetes, high blood pressure and obesity, which in turn reduces the risk of related disease.

Uncontrollable Risk Factors

Age, gender and family history are the three uncontrollable risk factors for CVD. While the factors themselves cannot be controlled, going for regular checkups is necessary so that proper precautionary measures can be put in place.

The doctors at Trinity Medical Group have had several years experience with diagnosing and treating cardiovascular disease. If you have any of the risk factors, don’t wait till it’s too late. Call Trinity Medical and make an appointment today. Also check out our new Blog Post on Symptoms of Cardiovascular Disease.

What Is Bradycardia?

Bradycardia is a type of arrhythmia characterized by reduced heart rate, which is less than 60 beats per minute (bpm). It can be considered as a variation of the norm in well-trained athletes, but most often it accompanies various cardiovascular pathologies. Slow heart rate is manifested by fatigue, semi-conscious state or transient loss of consciousness, cold sweats, darkening in the eyes, chest pain, dizziness, unstable levels of blood pressure; although, it can be asymptomatic as well.

If a person experiences any of the above symptoms, he or she should seek medical advice as soon as possible, since bradycardia can cause the following complications:

• Stokes-Adams attacks – periodic loss of consciousness. Such faints are followed by general muscle spasms, the pulse becomes too slow or undetectable, skin cover becomes very pale and breathing – deep;
• Sudden cardiac arrest;
• Arterial hypertension or unstable blood pressure;
• Coronary heart disease, effort or rest (unstable) angina pectoris;
• Development of chronic circulatory failure.

Pathological bradycardia can be the symptom of the following:
• Hypothyroidism – reduced production of thyroid hormones;
• Cardiovascular disorders like myocardial infarction, endocarditis or myocarditis;
• Acute intoxication (lead, pesticides, nicotine, narcotic substances);
• Traumatic brain injury, increased intracranial pressure;
• Infections such as typhoid, viral hepatitis, sepsis;
• Side effect of certain medications, for example, beta-blockers, cardiac glycosides, etc.

However, regardless of the cause of bradycardia, disturbed function of the sinus node (it means it cannot synthesize electrical impulses with the rate over 60 bpm) or inadequate spread of the impulses through the conduction pathways lie at the heart of this condition.

Preventive measures of bradycardia may include control and management of blood pressure and heart rate, healthy diet (reduced fat and salt consumption), smoking cessation and adequate alcohol consumption, maintenance of the work-rest regimen, fresh air, and regular physical activity. Annual medical check-ups will help to detect and cure any type of bradycardia.

Here are the basic principles of bradycardia treatment:
• If the heart rate is less than 60 bpm but no diseases of the cardiovascular system or other body organs are found, it’s enough to apply preventive measures;
• The treatment of an underlying disease that provokes bradycardia;
• Change in the medications that can cause bradycardia;
• Severe bradycardia (heart rate less than 40 beats per minute) that leads to the development of heart failure can require a surgery to implant a pacemaker.

Dangerous forms of bradycardia require emergency treatment and hospitalization of the patient. Self-treatment is not an option.

CAD: Coronary Artery Disease

Coronary heart disease, Coronary artery disease (CAD) and Ischemic heart disease (IHD) are synonyms and includes a bunch of disease like stable angina, unstable angina, myocardial infarction and sudden cardiac death.

Coronary heart disease develops when the arteries that supply blood and oxygen to the heart itself gets blocked due to the cholesterol or other substances gets deposited on the inner side of the blood vessels called the plaque, this narrowing of arteries is called atherosclerosis or arteriosclerosis. If it takes place in one of the major heart supplying arteries then it causes heart attack, stroke or peripheral arterial disease (PAD).

It reduces the elasticity of the blood vessels or narrows the inside area restricting the normal flow of the blood. It leads to the deficiency of oxygen in the heart muscles and causes chest pain also called angina.

Angina can be of two types:

Stable angina is the chest pain which occurs regularly with different activities. Unstable angina is when angina changes its intensity, also it can lead to myocardial infarction.

CAD weakens the blood muscles and leads to reduced functioning of heart in pumping the blood into the body, this is called heart failure. This also develops irregular heartbeat or arrhythmia.

Sometimes the plaque ruptures, gets stuck up in the artery somewhere and totally blocks the blood flow leading to oxygen cut off from that particular area causing permanently damaged heart muscle or scarring of them.

Causes: It is caused due to the cholesterol deposition on the inner lining of the blood vessels of the heart muscles.

Symptoms: Initial detection of the disease is done through its symptoms which are:
• shortness of breath (dyspnea)
• chest pain (discomfort in the chest and increasing into travel into the shoulder, arm, back, neck, or jaw)
• sweating
• nausea
• indigestion
• heartburn
• weakness

At risk: People with risk of getting IHD are/with:
• hypertensive
• smokers
• diabetic
• obese
• high blood cholesterol
• High resting heart rate
• Depression and stress
• Kidney disease
• Family history
• lack of exercise
• poor diet
• excessive alcohol intake
• 40 years old men and women are at great risk of developing this disease.

Diagnostic test: There are many test which help in the diagnosis of CAD:
• ECD or EKD: To measure electrical activity, rate and regularity of heartbeat.
• Chest X-ray: Pictures the heart, lungs and other organs of the chest.
• Echocardiogram: Ultrasound waves are used to picture the heart.
• Exercise stress test (EST): While walking on the treadmill, heart rate is measured.
• Cardiac catheterization: Checks the blockage in the heart arteries by inserting a thin, flexible tube through an artery in the groin, arm or neck to reach the heart to collect blood samples and to inject dye.
• Coronary angiogram: Injected dye is detected via X-rays point out the blocked areas in the arteries.

Prevention: To keep the disease at bay people need to control with medication and keep:
• Blood pressure
• Diabetes
• Cholesterol
• Proper diet
• Regular exercise
• Less alcohol intake

Management: Changes in the lifestyle is very helpful in living fit and healthy. Medications which help in managing the disease includes:
• Antiplatelet like aspirin
• Statins
• Beta blockers
• Calcium antagonists
• Angiotensin-converting enzyme (ACE) inhibitors
• Nitroglycerin.

Some procedures are also done to increase the inner width of the arteries like percutaneous coronary intervention (PCI) like coronary stent and angioplasty or coronary artery bypass grafting (CABG).

Aspirin and Your Heart

Aspirin is an anti-inflammatory and anti-platelet drug, and is used to treat pain, fever, blood clots, heart disease, heart attacks, and strokes. Aspirin has been proven to prevent heart attacks and strokes, especially in men over fifty. Your doctor will advise you which dosage is best for you. It is typically 81 mg or 325 mg by mouth once a day.

The benefits of taking aspirin daily include if you:
Have had a heart attack or chest pain
Had open heart surgery
Had coronary angioplasty (a procedure where a balloon is inserted to open blocked arteries and veins of your heart)
Had a stroke or TIA (Transient Ischemic Attack)
Have peripheral vascular disease (PVD)
Have heart rhythm problems, such as atrial fibrillation (A.Fib)

Risks of taking aspirin every day include minor bleeding or bruising, worsening of asthma, upset stomach, or allergic reaction. Children should not be given aspirin due to the risk of Reye’s syndrome (rapidly progressive brain dysfunction). Contraindications for use of aspirin include allergies to NSAID’s (non-steroidal anti-inflammatory drugs), peptic ulcers, GERD (gastroesophageal reflux disorder) or gastritis, hemophilia, kidney disease, and gout. Make sure your doctor is aware if you are taking more than one blood thinner, such as Plavix, or Ibuprofen.

There are 2 forms of aspirin you can take. Please ask your doctor which is the best one for you. The first type is called non-enteric coated. This means the aspirin does not have a protective coating that keeps your stomach from being upset, but is best to take when having active chest pain. This type comes in a chewable form. The enteric coated aspirin has the protective covering that keeps your stomach safe. This type cannot be chewed or crushed. Do not take any aspirin with alcohol as it increases chance of bleeding and stomach distress.

Signs of heart attack may include chest pain, left arm, jaw, or shoulder pain, or upper abdominal symptoms, such as, pain, or nausea. Stoke symptoms include one sided weakness, confusion, slurred speech, and facial drooping. If you think you are having a heart attack, call 911 first, the operator might ask you to take the aspirin. If you think you are having a stroke do Not take an aspirin. Strokes can be caused by bleeding in the brain, and aspirin can worsen the bleeding.

Please seek immediate medical attention if you have an allergic reaction, stools are black or bloody, vomit or cough up blood, there if blood is in your urine or you feel shortness of breath.

Caring for Your Heart

Leading a healthy and active lifestyle not only ensures that a person can remain active well into their latter years but it confirms that the most important organ in the human body is well cared for. There are a number of body parts that humans can do without but the heart is not one of them and over an average lifetime it beats millions of times. This means that blood is pumped to every part of the body and the brain and its functions benefit from this.

Lack of activity and an unhealthy diet can have an adverse affect on the vital role of the heart resulting in an even greater strain on this organ, forcing it to work much harder than it needs to. Ongoing abuse like this can culminate in a heart attack or complete heart failure. If a victim is lucky, a heart attack may not be fatal but the clinical care and sacrifices that have to be made after such an event can take many months and untold hours of sacrifice for the victim and their family.

There are many people who adopt the mindset that “you have got to die sometime”, but there is no substitute for quality of life. Many people who have experienced severe heart problems adjust their way of thinking after the length of time that it takes to get over the warning they have received. These are the lucky ones because many people who experience such problems do not live through the ordeal.

There is no doubt that the lazy attitude which has developed over recent years has put immense pressure on the health service of many nations. This, in turn, causes the problems that many have to endure if they have to visit a hospital: long waiting times, cancelled appointments and procedures and rushed face-to-face consultations.

All of this is brought about because medical staff are under so much pressure and their frequently increased patient numbers see them working longer hours at the expense of their own health. This is the reason why many professionals leave the health service.

So, remaining lazy and not caring for yourself can have a drastic outcome on family members who have to take control of your rehabilitation after a health scare as well as the health care professionals whose medical expertise is needed to ensure that you do not die on the operating table.

Finally, to add to the pressure of these professionals there is always somebody who feels they were hard done by and instigates legal proceedings if the results do not go their way.

Is It Safe to Exercise With Tachycardia?

Tachycardia is characterized by the heart rate that is over 100 beats per minute which is above the normal readings of heart rate. This condition is among the most common types of arrhythmia. An episode of tachycardia can be accompanied by any of these symptoms: dizziness, palpitations, anxiety, pulsation of the vessels in the neck, or even fainting. In those patients who already have a cardiovascular pathology, tachycardia can provoke the development of heart failure and aggravate their life prognosis.

However, tachycardia can also be observed in healthy people due to:

  • The use of certain drugs, drinking alcohol, coffee or strong tea;
  • Physical or emotional stress;
  • Sudden body position change;
  • High atmospheric temperature, etc.

Therefore, depending on tachycardia cause it is divided into physiological and pathological tachycardia. Physiological tachycardia occurs in healthy individuals as a physiological response of the healthy heart muscle to different external impacts. Pathological, on the other hand, develops against the background of various disorders. It can be dangerous because it causes lowering of the cardiac output volume and some intracardiac hemodynamics disorders. High heart rate that causes decreased blood filling of the ventricles provokes decrease in blood pressure, poor blood circulation and hypoxia development. However, on its own, tachycardia is more often a symptom and not a separate disorder.

They say that sport is good for a human health, but is it safe to exercise for patients with tachycardia? Experts say that for most people with tachycardia moderate and regular exercise is acceptable and encouraged. Nevertheless, in some patients with tachycardia, when it’s accompanied by certain conditions, exercising is strictly prohibited since it can cause life-threatening complications. The list of such conditions includes:

  • Cardiac aneurysm;
  • Recent heart attack;
  • Aortic aneurysm;
  • Paroxysmal supraventricular tachycardia;
  • Ventricular extrasystole;
  • Kidney or liver malfunction;
  • Severe hypertension, etc.

So, once diagnosed with tachycardia, a patient should first of all see a cardiologist, obtain an approval for exercising and develop a safe plan of physical activity together with a physician. It’s important to remember that physical activity should not be exhausting and too intense. If a patient has a history of any cardiac diseases, it’s recommended to begin an exercise program in a safe and monitored environment. In other cases, it’s better to begin exercising slowly and eventually develop exercise tolerance. If a patient is new to regular exercise, it’s recommended to begin with walking for 5-10 minutes and then, little by little, increase the time and distance. While increasing the intensity of physical activity, the patient should be able to tolerate it and be comfortable with it. If physical activity is accompanied by chest pain, palpitations or lightheadedness, that should be the sign for the patient to lower the intensity of the exercise routine.

Richard Johnson is a writer with a serious passion for health. He enjoys writing about healthy lifestyle encouraging people to take control of their health.

What Is Chronic Heart Failure? What Are the Regular & Phenomenal Causes of Chronic Heart Failure?

What is Chronic Heart Failure?

Heart failure is a term used to portray the state when the heart is never again ready to keep up its capacity – that is, to keep up a sufficient cardiovascular yield (to pump blood satisfactorily) or to have the capacity to do as such simply because it is under so much strain that it is causing itself harm. As it were, the heart is debilitated and the pumping activity is disabled causing heart failure. The heart does not totally come up short or quit working (as in a heart, a circumstance in which the heart really quits thumping), however rather works less adequately. Heart failure can go ahead rapidly in light of some significant occasion like a heart assault, or all the more gradually. In these moderate cases, the heart regularly adjusts to working harder and remunerates great for some time, however inevitably can’t adapt and individuals begin to have manifestations. For wellbeing worries on heart conditions counsel your specialist.

Regular Causes of Chronic Heart Failure

• Heart Disease where the heart is not getting enough oxygen.
• Past heart assault
• Hypertension
• Diabetes: Pairs the danger of creating perpetual heart failure in men and builds chance five times for ladies

Less Common Causes of Chronic Heart failure

• Expanded Cardiomyopathy: A condition where the heart just gets greater and more extensive, without a known reason.
• Valvular Heart Disease: Particularly aortic stenosis, where blood experiences difficulty moving beyond one of the real valves in the heart.

Phenomenal Causes of Chronic Heart

• Valvular Heart Disease: Particularly mitral and aortic spewing forth (additionally called ‘flawed valves’, where blood can stream back through them).
• Alcoholic Cardiomyopathy: an excess of liquor can make the heart get greater, influencing it to pump less effectively.
• Irritation of the heart muscle, or myocarditis
• Incessant arrhythmias
• HIV-related cardiomyopathy
• A few medications, particularly the truly risky ones, can cause heart harm
• Prohibitive Cardiomyopathy: the heart is quit pulsating adequately by something ceasing it, which can be of obscure reason, or can be optional to infiltrative infections, for example, amyloidosis

Way of life Factors influencing Chronic Heart Failure

• Smoking
• Obesity
• Abundance liquor utilization
• High salt consumption
• High fat food

A few patients who have heart failure are not by any means mindful of the issue until the point that it advances to a more genuine frame, called congestive heart failure. The expression “congestive” alludes to a liquid development that happens when the heart gets behind in its work. Since the heart is not proficient in directing blood out, there is less blood leaving the heart and hence the blood that profits to the heart gets went down. These outcomes in an expansion in weight causing drainage into encompassing tissue. All the time it is at this phase, patients begin seeing indications and looking for offer assistance.

Regular indications of interminable heart failure include:

Shortness of breath on work out: while this can begin just incident with work out, in the long run it can get so terrible that there is breathlessness on simply strolling, or not withstanding when very still. Shortness of breath on resting (orthopnoea): much of the time individuals say that they are requiring more cushions to ‘prop themselves up’ during the evening, else they get shy of breath. Assaults of breathlessness around evening time that wake you up. This has the therapeutic name of Paroxysmal Nocturnal Dyspnoea. Heart Palpitations where you can feel your heart pulsating in your chest Loss of hunger, acid reflux, Sickness and spewing In the event that Chronic Heart failure gets awful, liquid can develop, prompting swollen feet and lower legs.

Clinical Examination of Chronic Heart

On the off chance that a patient present with manifestations that could mean endless heart failure, at that point they will need to inspect loads of various frameworks of the body. Right off the bat, parcels can be learnt just from general assessment of how agreeable a man is by their rate of breathing and their heart rate. This is particularly critical on resting, as in unending heart failure shortness of breath is typically exacerbated much when laying level. Next, they might need to inspect the patient’s neck veins, as they can give data about how the correct side of the heart is working, and can indicate whether any blood is being pushed once more into them because of defective heart valves. After this, the specialist will need to inspect the patient’s chest where now and then the beat of the heart can be seen through the chest divider. This can give a thought with reference to how enormous the heart is and where it sits in the chest. They will then need to tune in to the heart which can give data about blood stream and furthermore about the valves. The specialist will then need to tune in to the lungs. This is on the grounds that in unending heart failure, liquid can ‘develop’ behind the left heart and begin pooling in the lungs in a condition called pneumonic oedema. This liquid makes little crackles called crepitation’s that can be heard with a stethoscope. Examination will then move to different regions like the liver, which can end up noticeably extended and delicate in perpetual heart failure. This is a direct result of the weight developing on this side of the heart and blood not having the capacity to leave the liver and it should. The specialist will likewise need to check with the expectation of complimentary liquid called ‘oedema’ in zones that it is probably going to deplete to, for example, your lower legs and back. This oedema liquid develops in light of the fact that the blood is not being pumped effectively through the heart. This causes a great deal of weight in the veins that bring blood back towards the heart, driving liquid out of the veins and into the tissues.

How is Chronic Heart Failure Diagnosed?

There are heaps of tests that a specialist can do in ceaseless heart failure. These tests can be utilized for diagnosing the condition and in addition working out exactly how extreme it is. In the first place, the specialist might need to do some blood tests to keep an eye on kidney work, liver capacity, thyroid capacity and the measure of cells in the blood. There are additionally two hormones found in the councils of the heart called ANP and BNP. These are discharged when the heart is extended (as occurs in unending heart failure) thus these can likewise be tried for. Next, the specialist might need to work out exactly how much exercise and action a patient is able to do. There are a few tests for this:

• Six Minute Walk: A six moment walk test includes strolling a roundabout track of 25m the same number of times as is conceivable in six minutes. On the off chance that a man begins strolling less and less each time then it is a sign the ailment is deteriorating.
• Exercise Testing: This includes getting on a bicycle or treadmill and working out how much exercise a man can do.

There are likewise some different sorts of particular tests that might be done if the specialist things they will be useful:

• Electrocardiogram (ECG): This measures the electrical movement of the heart and can give bunches of data about any variations from the norm.
• Chest x-beam: There are bunches of changes in a x-beam that are caused by heart failure.
• Echocardiography: This resembles a ultrasound of your heart, and can give data about blood streams and the capacity of the valves.
• Coronary Angiography: This includes setting some color through a little tube into the heart vessels and seeing where the color streams to, giving a smart thought about blood stream to the heart.
• Atomic Cardiology: Nuclear sweeps, for example, Cardiac PET can give some helpful data about blood stream to the heart.
• Spirometry: This test checks how well the lungs are functioning and can prohibit different reasons for windedness, particularly in smokers.

How is Chronic Heart Failure Treated?

There are a few techniques for treatment that intend to enhance both the indications and life expectancy of those misery from constant heart failure. Way of life changes in chronic heart failure.

Enhanced Diet and Weight Loss: This will enhance both exercise resilience and personal satisfaction. Lessening in soaked fats is especially essential in the individuals who have poor blood stream to the heart. Exercise is especially imperative in somebody with cardiovascular failure. Some of the time, the yield of the heart can be so awful in ceaseless heart failure, that very little blood gets to the gastrointestinal framework and this can prompt obstruction, so high-fiber eating methodologies are normally suggested. Additionally, if a major supper is eaten then a considerable measure of blood is required in the digestive organs to take every one of the supplements away which implies that it is occupied from different parts of the body. This can prompt so little blood.

How Mice and Zebrafish Are Unlocking Clues to Repairing Damaged Hearts

Unexpected that unassuming mice and zebrafish can help repair damaged hearts, a new study has revealed.

The zebrafish has the ability to stitch its severed spine again and the mouse has a substance surrounding its hearts that can patch up the injured or broken heart.

The researchers injected the extracellular matrix of the zebrafish into the damaged cardiac tissue of a mouse. The Zebrafish cellular matrix enhanced the cell replication, tissue regeneration and also improved the functioning of the heart in the mouse. The research reveals that proteins play a very important role in this transformation.

The power to heal quickly is seen only in super humans and is referred to as a super ability. Humans cannot re-grow their limbs like starfish. But children who lose their fingertips provided the nail is still safe have found that their tips can re-grow again. With age this ability gets turned off. The study along with research is to help study the MNDCM so this ability can be turned on again.

Every year a few lakh suffer from heart attacks and blocked arteries. A blocked artery deprives the heart of blood and oxygen its basic fuel. The longer the blockage lasts the more cells die and the heart is damaged permanently.

When children are born they have a large number of heart muscle cells called mononuclear diploid cardiomyocyte or MNDCM. These cells have regenerative properties and can rebuild the heart muscle. But as we grow older the cells reduce leading to a heart attack. MNDCM are few and hence are not able to repair the damage caused by the heart attack.

After an attack the healing is a long process and once the cells are damaged the muscle cells cardiomyocytes are replaced by scared tissue, which cannot contract and pump. This further increases the stress on the remaining heart muscle and then leads to heart failure.

The researchers have found that a few mice have less than two percent of the MNDCMs while others have it in a larger percentage. Thus, those mice with a higher number of MNDCMs are able to regenerate the heart muscle after an injury or a heart attack. A wide genetic study has revealed the gene Tnni3k that plays a major role in generating the MNDCMs.

Turning off the Tnni3k gene resulted the increased number of MNDCMs thus increasing the ability to regenerate the heart. But when the same gene Tnni3k was activated in the zebrafish it reduced the number of MNDCMs and destroyed its ability to repair damaged heart.

But it’s still a long way from being used on humans. This study is just the first step towards evolving a medicine. The Tnni3k can be modulated and hence can be used to create prescription medicine. The Tnni3k overtime can help contain more regenerative cells in adult hearts and prevent heart failure.

The ultimate goal of this research is regeneration of the cells to heal the body. Quick healing is useful in a young child, the body needs to regenerate.

Tnni3k in zebrafish promoted cardiomyocyte compromised heart regeneration. The results corroborate the importance of MNDCMs in heart regeneration. It implies that heart regeneration is not same in every individual, but it is influenced by many genes.

It is likely that several things influence the functional and morphological outcome after a heart injury, which includes cardiomyocyte proliferation, cardiomyocyte hypertrophy, collagen deposition by fibroblasts (scarring), regrowth of coronary vasculature etc.

Heart Disease Is the No.1 Killer and We Know How to Prevent It – Why Don’t We?

In my conversations with my patients, they are often surprised by 2 facts that don’t seem to go together.

1. That heart disease is the leading cause of death and disability in the world.

2. That the vast majority of heart disease is preventable.

And you also may think, how can this be? How can the leading cause of death and disability be mostly preventable and yet remain the leading cause of death and disability?

The answer of course is complex, but here is why I believe we can’t rely on others to look out for our heart’s health. We need to do it ourselves.

Losing the War

It is clear that we are losing the war on heart disease. Sure we have amazing procedures and medications, but they can only do so much. Heart disease remains the leading cause of death and disability in the world.

What is particularly troublesome about this is that we know exactly how to keep your Heart healthy. Take care of 7 common sense aspects of health and your risk of heart disease is decreased by 80%. Really, 80%!

And the benefits don’t end with the Heart. These 7 good health factors cut your risk of stroke by 50%, your risk of cancer by a third and are the most effective ways to prevent dementia.

Life’s Simple 7

What are these 7 magical things? The American Heart Association calls them “Life’s Simple 7” and they are:

  • Get Active
  • Stop Smoking
  • Eat Better
  • Manage Blood Pressure
  • Control Cholesterol
  • Reduce Blood Sugar
  • Lose Weight

So, not particularly surprising, mostly common sense, but when taken care of, remarkably effective at improving health, the length and the quality of life.And how are we doing with this knowledge?

By just about any criteria, the answer is poorly. More than 9 million people die each year from heart disease. When you add stroke (the combination of stroke and heart attacks doctors call cardiovascular disease), that is 15 million deaths per year or about a death every 2 seconds)

Now back to our original question. How can this be? How can the leading cause of death and disability be mostly preventable and yet remain the leading cause of death and disability?

Follow the Money

It’s a good question, and no doubt the reasons are complex, but one factor undoubtedly is that a lot of money is made when we are sick.

The financial success of the tobacco industry, the fast food industry, the soft drink industry, the healthcare industry, the pharmaceutical industry and many others depends on you making choices that make your heart sick.

But it doesn’t have to be that way. You don’t have to pay the bottom line of big industry with your life. It is important for you to know that your future health is in your hands.

I will continue to talk about simple steps that can keep your heart in the game.

Because You – and your heart – deserve it.

I am a cardiologist with a goal to build a healthy community of informed people sharing up to date information, dialogue and techniques about keeping your heart from being a statistic. You will find at my website current information and help with eating right, exercise, stress relief, weight loss and more. You can also email me directly from my website for help and information. I read all of my emails. Lets get together to beat the system and create a large Healthy Community.